Elucidation of the Hdac2/Sp1/miR-204-5p/Bcl-2 axis as a modulator of cochlear apoptosis via in vivo/in vitro models of acute hearing loss

• Main Authors: Lisheng Xie (Author), Qiongqiong Zhou (Author), Xiaorui Chen (Author), Xiaoping Du (Author), Zhibiao Liu (Author), Bing Fei (Author), Jie Hou (Author), Yanhong Dai (Author), Wandong She (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously reported that dysregulation of histone deacetylase 2 (Hdac2) was associated with the prognosis of sudden sensorineural hearing loss. However, the underlying molecular mechanisms are poorly understood. In the present study, we developed an acute hearing loss animal model in guinea pigs...