Empagliflozin increases kidney weight due to increased cell size in the proximal tubule S3 segment and the collecting duct

• Main Authors: Frederick Sinha (Author), Anna Federlein (Author), Annika Biesold (Author), Magdalena Schwarzfischer (Author), Katharina Krieger (Author), Frank Schweda (Author), Philipp Tauber (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The inhibition of renal SGLT2 glucose reabsorption has proven its therapeutic efficacy in chronic kidney disease. SGLT2 inhibitors (SGLTi) have been intensively studied in rodent models to identify the mechanisms of SGLT2i-mediated nephroprotection. So far, the overwhelming effects from clinical tri...