A machine learning framework for genotyping the structural variations with copy number variant

• Main Authors: Tian Zheng (Author), Xiaoyan Zhu (Author), Xuanping Zhang (Author), Zhongmeng Zhao (Author), Xin Yi (Author), Jiayin Wang (Author), Hongle Li (Author)
• Format: Book
• Published: BMC, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Genotyping of structural variation is an important computational problem in next generation sequence data analysis. However, in cancer genomes, the copy number variant(CNV) often coexists with other types of structural variations which significantly reduces the accuracy of the ex...