Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade.

• Main Authors: Manu De Rycker (Author), John Thomas (Author), Jennifer Riley (Author), Stephen J Brough (Author), Tim J Miles (Author), David W Gray (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chagas disease is a significant health problem in Latin America and the available treatments have significant issues in terms of toxicity and efficacy. There is thus an urgent need to develop new treatments either via a repurposing strategy or through the development of new chemical entities. A key...