Characterization of CPH:SA microparticle‐based delivery of interleukin‐1 alpha for cancer immunotherapy

• Main Authors: M. M. Hasibuzzaman (Author), Rui He (Author), Ishrat Nourin Khan (Author), Rasna Sabharwal (Author), Aliasger K. Salem (Author), Andrean Llewela Simons‐Burnett (Author)
• Format: Book
• Published: Wiley, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Interleukin‐1 alpha (IL‐1α) is a pro‐inflammatory cytokine that can activate immune effector cells and trigger anti‐tumor immune responses. However, dose‐limiting toxicities including cytokine storm and hypotension has limited its use in the clinic as a cancer therapy. We propose...