Characterization of CPH:SA microparticle‐based delivery of interleukin‐1 alpha for cancer immunotherapy

• Главные авторы: M. M. Hasibuzzaman (Автор), Rui He (Автор), Ishrat Nourin Khan (Автор), Rasna Sabharwal (Автор), Aliasger K. Salem (Автор), Andrean Llewela Simons‐Burnett (Автор)
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• Опубликовано: Wiley, 2023-05-01T00:00:00Z.
• Предметы: article
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Abstract Background Interleukin‐1 alpha (IL‐1α) is a pro‐inflammatory cytokine that can activate immune effector cells and trigger anti‐tumor immune responses. However, dose‐limiting toxicities including cytokine storm and hypotension has limited its use in the clinic as a cancer therapy. We propose...