Donepezil Potentiates Nerve Growth Factor-Induced Neurite Outgrowth in PC12 Cells

• Main Authors: Toru Oda (Author), Toshiaki Kume (Author), Hiroshi Katsuki (Author), Tetsuhiro Niidome (Author), Hachiro Sugimoto (Author), Akinori Akaike (Author)
• 格式: 圖書
• 出版: Elsevier, 2007-01-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Donepezil is a potent and selective acetylcholinesterase inhibitor developed for the treatment of Alzheimer's disease. To elucidate whether donepezil causes neuronal differentiation, we examined its effect on nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. Donepezil (10 µM) s...