<i>Carnosinase-1</i> Knock-Out Reduces Kidney Fibrosis in Type-1 Diabetic Mice on High Fat Diet

• Main Authors: Tilman Pfeffer (Author), Charlotte Wetzel (Author), Philip Kirschner (Author), Maria Bartosova (Author), Tanja Poth (Author), Constantin Schwab (Author), Gernot Poschet (Author), Johanna Zemva (Author), Ruben Bulkescher (Author), Ivan Damgov (Author), Christian Thiel (Author), Sven F. Garbade (Author), Kristina Klingbeil (Author), Verena Peters (Author), Claus Peter Schmitt (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Carnosine and anserine supplementation markedLy reduce diabetic nephropathy in rodents. The mode of nephroprotective action of both dipeptides in diabetes, via local protection or improved systemic glucose homeostasis, is uncertain. Global carnosinase-1 knockout mice (<i>Cndp1</i>-KO) an...