Immune-mediated myogenesis and acetylcholine receptor clustering promote a slow disease progression in ALS mouse models

• প্রধান লেখক: Cassandra Margotta (লেখক), Paola Fabbrizio (লেখক), Marco Ceccanti (লেখক), Chiara Cambieri (লেখক), Gabriele Ruffolo (লেখক), Jessica D'Agostino (লেখক), Maria Chiara Trolese (লেখক), Pierangelo Cifelli (লেখক), Veronica Alfano (লেখক), Christian Laurini (লেখক), Silvia Scaricamazza (লেখক), Alberto Ferri (লেখক), Gianni Sorarù (লেখক), Eleonora Palma (লেখক), Maurizio Inghilleri (লেখক), Caterina Bendotti (লেখক), Giovanni Nardo (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: BMC, 2023-03-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract Background Amyotrophic lateral sclerosis (ALS) is a heterogeneous disease in terms of onset and progression rate. This may account for therapeutic clinical trial failure. Transgenic SOD1G93A mice on C57 or 129Sv background have a slow and fast disease progression rate, mimicking the variabi...