Immune-mediated myogenesis and acetylcholine receptor clustering promote a slow disease progression in ALS mouse models

• Main Authors: Cassandra Margotta (Author), Paola Fabbrizio (Author), Marco Ceccanti (Author), Chiara Cambieri (Author), Gabriele Ruffolo (Author), Jessica D'Agostino (Author), Maria Chiara Trolese (Author), Pierangelo Cifelli (Author), Veronica Alfano (Author), Christian Laurini (Author), Silvia Scaricamazza (Author), Alberto Ferri (Author), Gianni Sorarù (Author), Eleonora Palma (Author), Maurizio Inghilleri (Author), Caterina Bendotti (Author), Giovanni Nardo (Author)
• Format: Book
• Published: BMC, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Amyotrophic lateral sclerosis (ALS) is a heterogeneous disease in terms of onset and progression rate. This may account for therapeutic clinical trial failure. Transgenic SOD1G93A mice on C57 or 129Sv background have a slow and fast disease progression rate, mimicking the variabi...