COX-2 Expression in Hepatocytes Improves Mitochondrial Function after Hepatic Ischemia-Reperfusion Injury

• Main Authors: Marina Fuertes-Agudo (Author), María Luque-Tévar (Author), Carme Cucarella (Author), Rocío Brea (Author), Lisardo Boscá (Author), Rubén Quintana-Cabrera (Author), Paloma Martín-Sanz (Author), Marta Casado (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cyclooxygenase 2 (COX-2) is a key enzyme in prostanoid biosynthesis. The constitutive hepatocyte expression of COX-2 has a protective role in hepatic ischemia-reperfusion (I/R) injury (IRI), decreasing necrosis, reducing reactive oxygen species (ROS) levels, and increasing autophagy and antioxidant...