Accurate detection of KRAS, NRAS and BRAF mutations in metastatic colorectal cancers by bridged nucleic acid-clamp real-time PCR

• প্রধান লেখক: Yuki Nagakubo (লেখক), Yosuke Hirotsu (লেখক), Kenji Amemiya (লেখক), Toshio Oyama (লেখক), Hitoshi Mochizuki (লেখক), Masao Omata (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: BMC, 2019-11-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract Background Patients with metastatic colorectal cancer can benefit from anti-EGFR therapy, such as cetuximab and panitumumab. However, colorectal cancers harboring constitutive activating mutations in KRAS, NRAS and BRAF genes are not responsive to anti-EGFR therapy. To select patients for a...