Accurate detection of KRAS, NRAS and BRAF mutations in metastatic colorectal cancers by bridged nucleic acid-clamp real-time PCR

• Glavni autori: Yuki Nagakubo (Autor), Yosuke Hirotsu (Autor), Kenji Amemiya (Autor), Toshio Oyama (Autor), Hitoshi Mochizuki (Autor), Masao Omata (Autor)
• Format: Knjiga
• Izdano: BMC, 2019-11-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract Background Patients with metastatic colorectal cancer can benefit from anti-EGFR therapy, such as cetuximab and panitumumab. However, colorectal cancers harboring constitutive activating mutations in KRAS, NRAS and BRAF genes are not responsive to anti-EGFR therapy. To select patients for a...