Deletion of Cryab increases the vulnerability of mice to the addiction-like effects of the cannabinoid JWH-018 via upregulation of striatal NF-κB expression

• Main Authors: Leandro Val Sayson (Author), Darlene Mae Ortiz (Author), Hyun Jun Lee (Author), Mikyung Kim (Author), Raly James Perez Custodio (Author), Jaesuk Yun (Author), Chae Hyeon Lee (Author), Yong Sup Lee (Author), Hye Jin Cha (Author), Jae Hoon Cheong (Author), Hee Jin Kim (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Synthetic cannabinoids have exhibited unpredictable abuse liabilities, especially self-administration (SA) responses in normal rodent models, despite seemingly inducing addiction-like effects in humans. Thus, an efficient pre-clinical model must be developed to determine cannabinoid abuse potential...