Deletion of Cryab increases the vulnerability of mice to the addiction-like effects of the cannabinoid JWH-018 via upregulation of striatal NF-κB expression

• Главные авторы: Leandro Val Sayson (Автор), Darlene Mae Ortiz (Автор), Hyun Jun Lee (Автор), Mikyung Kim (Автор), Raly James Perez Custodio (Автор), Jaesuk Yun (Автор), Chae Hyeon Lee (Автор), Yong Sup Lee (Автор), Hye Jin Cha (Автор), Jae Hoon Cheong (Автор), Hee Jin Kim (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Предметы: article
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Synthetic cannabinoids have exhibited unpredictable abuse liabilities, especially self-administration (SA) responses in normal rodent models, despite seemingly inducing addiction-like effects in humans. Thus, an efficient pre-clinical model must be developed to determine cannabinoid abuse potential...