Aldo keto reductases 1B in endocrinology and metabolism

• Main Authors: Emilie ePastel (Author), Jean-Christophe ePointud (Author), Fanny eVolat (Author), Antoine eMartinez (Author), Anne-Marie eLefr (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aldose reductase (human AKR1B1/mouse Akr1b3) has been the focus of many research because of its role in diabetic complications. The starting point of these alterations is the massive entry of glucose in polyol pathway where it is converted into sorbitol by this enzyme. However, the issue of aldo...