Mitochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis

• Main Authors: Torsten Schröder (Author), David Kucharczyk (Author), Florian Bär (Author), René Pagel (Author), Stefanie Derer (Author), Sebastian Torben Jendrek (Author), Annika Sünderhauf (Author), Ann-Kathrin Brethack (Author), Misa Hirose (Author), Steffen Möller (Author), Axel Künstner (Author), Julia Bischof (Author), Imke Weyers (Author), Jörg Heeren (Author), Dirk Koczan (Author), Sebastian Michael Schmid (Author), Senad Divanovic (Author), Daniel Aaron Giles (Author), Jerzy Adamski (Author), Klaus Fellermann (Author), Hendrik Lehnert (Author), Jörg Köhl (Author), Saleh Ibrahim (Author), Christian Sina (Author)
• Format: Book
• Published: Elsevier, 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is associated with an enhanced risk for liver and cardiovascular diseases and mortality. NAFLD can progress from simple hepatic steatosis to non-alcoholic steatohepatitis (NASH). However, the mechanisms...