Carvedilol Phenocopies PGC-1α Overexpression to Alleviate Oxidative Stress, Mitochondrial Dysfunction and Prevent Doxorubicin-Induced Toxicity in Human iPSC-Derived Cardiomyocytes

• Main Authors: Nnamdi Uche (Author), Qiang Dai (Author), Shuping Lai (Author), Kurt Kolander (Author), Mai Thao (Author), Elizabeth Schibly (Author), Xavier Sendaydiego (Author), Jacek Zielonka (Author), Ivor J. Benjamin (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Doxorubicin (DOX), one of the most effective and widely used anticancer drugs, has the major limitation of cancer treatment-related cardiotoxicity (CTRTOX) in the clinic. Reactive oxygen species (ROS) generation and mitochondrial dysfunction are well-known consequences of DOX-induced injury to cardi...