Affinity-controlled capture and release of engineered monoclonal antibodies by macroporous dextran hydrogels using coiled-coil interactions

• Main Authors: Seyed Farzad Baniahmad (Author), Romane Oliverio (Author), Ines Obregon-Gomez (Author), Alma Robert (Author), Anne E.G. Lenferink (Author), Elena Pazos (Author), Nick Virgilio (Author), Xavier Banquy (Author), Gregory De Crescenzo (Author), Yves Durocher (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTLong-term delivery is a successful strategy used to reduce the adverse effects of monoclonal antibody (mAb)-based treatments. Macroporous hydrogels and affinity-based strategies have shown promising results in sustained and localized delivery of the mAbs. Among the potential tools for affini...