Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors

• Main Authors: Moran Magdalene M (Author), del Camino Donato (Author), Kerstein Patrick C (Author), Stucky Cheryl L (Author)
• Format: Book
• Published: SAGE Publishing, 2009-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>TRPA1 has been implicated in both chemo- and mechanosensation. Recent work demonstrates that inhibiting TRPA1 function reduces mechanical hypersensitivity produced by inflammation. Furthermore, a broad range of chemical irritants req...