Targeting ulcerative colitis by suppressing glucose uptake with ritonavir

• Main Authors: Henrika Jodeleit (Author), Omar Al-Amodi (Author), Janina Caesar (Author), Christina Villarroel Aguilera (Author), Lesca Holdt (Author), Roswitha Gropp (Author), Florian Beigel (Author), Matthias Siebeck (Author)
• Format: Book
• Published: The Company of Biologists, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glucose is the preferred source of energy in activated inflammatory cells. Glucose uptake into the cell is ensured by a family of glucose uptake transporters (GLUTs), which have been identified as off-target molecules of the HIV protease inhibitor ritonavir. In this study, we examined the effect of...