Nanosuspensions and Microneedles Roller as a Combined Approach to Enhance Diclofenac Topical Bioavailability

• Main Authors: Rosa Pireddu (Author), Michele Schlich (Author), Salvatore Marceddu (Author), Donatella Valenti (Author), Elena Pini (Author), Anna Maria Fadda (Author), Francesco Lai (Author), Chiara Sinico (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Topical application of the anti-inflammatory drug diclofenac (DCF) reduces the severity of systemic unwanted effects compared to its oral administration. A number of transdermal formulations are available on the market and routinely used in clinical and home-care settings. However, the amount of DCF...