Selective inhibition of N-linked glycosylation impairs receptor tyrosine kinase processing

• Main Authors: Elsenoor Klaver (Author), Peng Zhao (Author), Melanie May (Author), Heather Flanagan-Steet (Author), Hudson H. Freeze (Author), Reid Gilmore (Author), Lance Wells (Author), Joseph Contessa (Author), Richard Steet (Author)
• Format: Book
• Published: The Company of Biologists, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Global inhibition of N-linked glycosylation broadly reduces glycan occupancy on glycoproteins, but identifying how this inhibition functionally impacts specific glycoproteins is challenging. This limits our understanding of pathogenesis in the congenital disorders of glycosylation (CDG). We used sel...