TSG-6 Inhibits Oxidative Stress and Induces M2 Polarization of Hepatic Macrophages in Mice With Alcoholic Hepatitis via Suppression of STAT3 Activation

• Main Authors: Yue-Meng Wan (Author), Hua-Mei Wu (Author), Yu-Hua Li (Author), Zhi-Yuan Xu (Author), Jin-Hui Yang (Author), Chang Liu (Author), Yue-Feng He (Author), Men-Jie Wang (Author), Xi-Nan Wu (Author), Yuan Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumor necrosis factor (TNF)-α-stimulated protein 6 (TSG-6) is a secreted protein with diverse tissue protective and anti-inflammatory properties. We aimed to investigate its effects in treating mice with alcoholic hepatitis (AH) and the associated mechanisms. AH was induced in 8-10 week female C57BL...