Gambogic amide inhibits angiogenesis by suppressing VEGF/VEGFR2 in endothelial cells in a TrkA-independent manner

• Main Authors: Tongtong Sui (Author), Bojun Qiu (Author), Jiaorong Qu (Author), Yuxin Wang (Author), Kunnian Ran (Author), Wei Han (Author), Xiaozhong Peng (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context Gambogic amide (GA-amide) is a non-peptide molecule that has high affinity for tropomyosin receptor kinase A (TrkA) and possesses robust neurotrophic activity, but its effect on angiogenesis is unclear. Objective The study investigates the antiangiogenic effect of GA-amide on endothelial cel...