Crebanine, an aporphine alkaloid, induces cancer cell apoptosis through PI3K-Akt pathway in glioblastoma multiforme

• Main Authors: Poh-Shiow Yeh (Author), Chien-Te Liu (Author), Chia-Ying Yu (Author), Ya-Chuan Chang (Author), Shu-Yu Lin (Author), Yun-Chen Li (Author), Yu-Ze Luan (Author), Wen-Wei Sung (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma multiforme (GBM) is one of the most prevalent and lethal primary central nervous system malignancies. GBM is notorious for its high rates of recurrence and therapy resistance and the PI3K/Akt pathway plays a pivotal role in its malignant behavior. Crebanine (CB), an alkaloid capable of...