The Ubiquitin-Specific Protease 18 Promotes Hepatitis C Virus Production by Increasing Viral Infectivity

• Main Authors: Yujia Li (Author), Max Xuezhong Ma (Author), Bo Qin (Author), Liang-Tzung Lin (Author), Christopher D. Richardson (Author), Jordan Feld (Author), Ian D. McGilvray (Author), Limin Chen (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Aims. Ubiquitin-specific protease 18 (USP18) is involved in immunoregulation and response to interferon- (IFN-) based treatment in patients chronically infected with hepatitis C virus (HCV). We investigated whether and how its upregulation alters HCV infection. Methods. Overexpression...