Demonstration of the Early Cardiac Bioavailability of a Non-Specific Cell-Targeted Peptide Using Radionuclide-Based Imaging In Vivo

• Egile Nagusiak: Stephan Settelmeier (Egilea), Zohreh Varasteh (Egilea), Magdalena Staniszewska (Egilea), Anna-Lena Beerlage (Egilea), Fadi Zarrad (Egilea), Wolfgang P. Fendler (Egilea), Christoph Rischpler (Egilea), Johannes Notni (Egilea), Matthias Totzeck (Egilea), Ken Herrmann (Egilea), Tienush Rassaf (Egilea), Ulrike B. Hendgen-Cotta (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2023-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The cardiac bioavailability of peptide drugs that inhibit harmful intracellular protein-protein interactions in cardiovascular diseases remains a challenging task in drug development. This study investigates whether a non-specific cell-targeted peptide drug is available in a timely manner at its int...