Demonstration of the Early Cardiac Bioavailability of a Non-Specific Cell-Targeted Peptide Using Radionuclide-Based Imaging In Vivo

• Main Authors: Stephan Settelmeier (Author), Zohreh Varasteh (Author), Magdalena Staniszewska (Author), Anna-Lena Beerlage (Author), Fadi Zarrad (Author), Wolfgang P. Fendler (Author), Christoph Rischpler (Author), Johannes Notni (Author), Matthias Totzeck (Author), Ken Herrmann (Author), Tienush Rassaf (Author), Ulrike B. Hendgen-Cotta (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cardiac bioavailability of peptide drugs that inhibit harmful intracellular protein-protein interactions in cardiovascular diseases remains a challenging task in drug development. This study investigates whether a non-specific cell-targeted peptide drug is available in a timely manner at its int...