Tideglusib, a prospective alternative to nonoxynol-9 contraceptive

• Main Authors: Zhiting Chen (Author), Niyan Shu (Author), Yuzhu Wang (Author), Yiting Yang (Author), Zhiyu Shao (Author), Fang Tian (Author), Minjie Xia (Author), Zhikai Wang (Author), Xin Wang (Author), Xing Feng (Author), Xianliang Huang (Author), Weihua Li (Author), Heguo Yu (Author), Hua Diao (Author)
• Format: Book
• Published: Elsevier, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: We aimed to evaluate the antifertility activity and vaginal irritation effects of tideglusib in vivo using rabbit models and to evaluate the cytotoxical effects of tideglusib to sperm, vaginal cells and vaginal bacteria (L. acidophilus) in vitro. Study design: We treated female rabbits w...