Transcriptional pathways of terminal differentiation in high- and low-density blood granulocytes in sepsis

• Main Authors: Tobias Guenther (Author), Anna Coulibaly (Author), Sonia Y. Velásquez (Author), Jutta Schulte (Author), Tanja Fuderer (Author), Timo Sturm (Author), Bianka Hahn (Author), Manfred Thiel (Author), Holger A. Lindner (Author)
• Format: Book
• Published: BMC, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Trauma and infection induce emergency granulopoiesis. Counts of immature granulocytes and transcriptional pathways of terminal granulocytic differentiation in blood are elevated in sepsis but correlate with disease severity. This limits their performance as sepsis biomarkers in c...