Synthesis and in silico study of 2-furyl(4-{4-[(substituted)sulfonyl]benzyl}-1-piperazinyl)methanone derivatives as suitable therapeutic agents

• Main Authors: Ghulam Hussain (Author), Muhammad Athar Abbasi (Author), Aziz- (Author), Sabahat Zahra Siddiqui (Author), Syed Adnan Ali Shah (Author), Muhammad Ashraf (Author), Qurat- (Author), Irshad Ahmad (Author), Rabia Malik (Author), Muhammad Arif Lodhi (Author), Farman Ali Khan (Author), Muhammad Shahid (Author), Hina Fatima (Author)
• Format: Book
• Published: Universidade de São Paulo, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract In the study presented here, a new series of 2-furyl(4-{4-[(substituted)sulfonyl]benzyl}-1-piperazinyl)methanone derivatives was targeted. The synthesis was initiated by the treatment of different secondary amines (1a-h) with 4-bromomethylbenzenesulfonyl chloride (2) to obtain various 1-{[4...