Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol

• 主要な著者: Tomoko Nishina (著者), Junna Numata (著者), Kazutaka Nishina (著者), Kie Yoshida-Tanaka (著者), Keiko Nitta (著者), Wenying Piao (著者), Rintaro Iwata (著者), Shingo Ito (著者), Hiroya Kuwahara (著者), Takeshi Wada (著者), Hidehiro Mizusawa (著者), Takanori Yokota (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2015-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

We developed an efficient system for delivering short interfering RNA (siRNA) to the liver by using α-tocopherol conjugation. The α-tocopherol-conjugated siRNA was effective and safe for RNA interference-mediated gene silencing in vivo. In contrast, when the 13-mer LNA (locked nucleic acid)-DNA gapm...