Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol

• Main Authors: Tomoko Nishina (Author), Junna Numata (Author), Kazutaka Nishina (Author), Kie Yoshida-Tanaka (Author), Keiko Nitta (Author), Wenying Piao (Author), Rintaro Iwata (Author), Shingo Ito (Author), Hiroya Kuwahara (Author), Takeshi Wada (Author), Hidehiro Mizusawa (Author), Takanori Yokota (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We developed an efficient system for delivering short interfering RNA (siRNA) to the liver by using α-tocopherol conjugation. The α-tocopherol-conjugated siRNA was effective and safe for RNA interference-mediated gene silencing in vivo. In contrast, when the 13-mer LNA (locked nucleic acid)-DNA gapm...