Inhibition of Gasdermin D-Mediated Pyroptosis Attenuates the Severity of Seizures and Astroglial Damage in Kainic Acid-Induced Epileptic Mice

• Κύριοι συγγραφείς: Lu Xia (Συγγραφέας), Lu Liu (Συγγραφέας), Yiying Cai (Συγγραφέας), Yiying Zhang (Συγγραφέας), Fangchao Tong (Συγγραφέας), Qiang Wang (Συγγραφέας), Jing Ding (Συγγραφέας), Xin Wang (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Objective: Our study aimed to explore whether gasdermin D (GSDMD)-mediated pyroptosis is involved in the mechanism of kainic acid-induced seizures.Methods: C57BL/6 mice were randomly divided into sham and epilepsy groups. The epilepsy group was intrahippocampally injected with kainic acid to induce...