Inhibition of Gasdermin D-Mediated Pyroptosis Attenuates the Severity of Seizures and Astroglial Damage in Kainic Acid-Induced Epileptic Mice

Objective: Our study aimed to explore whether gasdermin D (GSDMD)-mediated pyroptosis is involved in the mechanism of kainic acid-induced seizures.Methods: C57BL/6 mice were randomly divided into sham and epilepsy groups. The epilepsy group was intrahippocampally injected with kainic acid to induce...

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Main Authors: Lu Xia (Author), Lu Liu (Author), Yiying Cai (Author), Yiying Zhang (Author), Fangchao Tong (Author), Qiang Wang (Author), Jing Ding (Author), Xin Wang (Author)
Format: Knjiga
Izdano: Frontiers Media S.A., 2022-01-01T00:00:00Z.
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