Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction

• Main Authors: Esraa Shosha (Author), Abdelrahman Y. Fouda (Author), Tahira Lemtalsi (Author), Stephen Haigh (Author), David Fulton (Author), Ahmed Ibrahim (Author), Mohamed Al-Shabrawey (Author), R. William Caldwell (Author), Ruth B. Caldwell (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Retinal ischemic disease is a major cause of vision loss. Current treatment options are limited to late-stage diseases, and the molecular mechanisms of the initial insult are not fully understood. We have previously shown that the deletion of the mitochondrial arginase isoform, arginase 2...