The Chondroprotective Agent ITZ-1 Inhibits Interleukin-1β-Induced Matrix Metalloproteinase-13 Production and Suppresses Nitric Oxide- Induced Chondrocyte Death

• Main Authors: Haruhide Kimura (Author), Hiroshi Yukitake (Author), Hirobumi Suzuki (Author), Yasukazu Tajima (Author), Koyo Gomaibashi (Author), Shinji Morimoto (Author), Yasunori Funabashi (Author), Kiyofumi Yamada (Author), Masayuki Takizawa (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: In a screening program aimed at discovering anti-osteoarthritis (OA) drugs, we identified an imidazo[5,1-c][1,4]thiazine derivative, ITZ-1, that suppressed both interleukin-1β (IL-1β)-induced proteoglycan and collagen release from bovine nasal cartilage in vitro and suppressed intra-artic...