The Chondroprotective Agent ITZ-1 Inhibits Interleukin-1β-Induced Matrix Metalloproteinase-13 Production and Suppresses Nitric Oxide- Induced Chondrocyte Death

• Автори: Haruhide Kimura (Автор), Hiroshi Yukitake (Автор), Hirobumi Suzuki (Автор), Yasukazu Tajima (Автор), Koyo Gomaibashi (Автор), Shinji Morimoto (Автор), Yasunori Funabashi (Автор), Kiyofumi Yamada (Автор), Masayuki Takizawa (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2009-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract.: In a screening program aimed at discovering anti-osteoarthritis (OA) drugs, we identified an imidazo[5,1-c][1,4]thiazine derivative, ITZ-1, that suppressed both interleukin-1β (IL-1β)-induced proteoglycan and collagen release from bovine nasal cartilage in vitro and suppressed intra-artic...