Fluoxetine and Vortioxetine Reverse Depressive-Like Phenotype and Memory Deficits Induced by Aβ1-42 Oligomers in Mice: A Key Role of Transforming Growth Factor-β1

• Main Authors: Sebastiano Alfio Torrisi (Author), Federica Geraci (Author), Maria Rosaria Tropea (Author), Margherita Grasso (Author), Giuseppe Caruso (Author), Annamaria Fidilio (Author), Nicolò Musso (Author), Giulia Sanfilippo (Author), Fabio Tascedda (Author), Agostino Palmeri (Author), Salvatore Salomone (Author), Filippo Drago (Author), Daniela Puzzo (Author), Gian Marco Leggio (Author), Filippo Caraci (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Depression is a risk factor for the development of Alzheimer's disease (AD), and the presence of depressive symptoms significantly increases the conversion of mild cognitive impairment (MCI) into AD. A long-term treatment with antidepressants reduces the risk to develop AD, and different second...