The studies of PLGA nanoparticles loading atorvastatin calcium for oral administration in vitro and in vivo

• Main Authors: Zhenbao Li (Author), Wenhui Tao (Author), Dong Zhang (Author), Chunnuan Wu (Author), Binbin Song (Author), Shang Wang (Author), Tianyang Wang (Author), Mingming Hu (Author), Xiaohong Liu (Author), Yongjun Wang (Author), Yinghua Sun (Author), Jin Sun (Author)
• Format: Book
• Published: Elsevier, 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A biodegradable poly(lactic-co-glycolic acid) loading atorvastatin calcium (AC) nanoparticles (AC-PLGA-NPs) were prepared by probe ultrasonication and evaporation method aiming at improving the oral bioavailability of AC. The effects of experimental parameters, including stabilizer species, stabiliz...