Matrix Metalloproteinase-2 Inhibition in Acute Ischemia-Reperfusion Heart Injury-Cardioprotective Properties of Carvedilol

• Main Authors: Monika Skrzypiec-Spring (Author), Joanna Urbaniak (Author), Agnieszka Sapa-Wojciechowska (Author), Jadwiga Pietkiewicz (Author), Alina Orda (Author), Bożena Karolko (Author), Regina Danielewicz (Author), Iwona Bil-Lula (Author), Mieczysław Woźniak (Author), Richard Schulz (Author), Adam Szeląg (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Matrix metalloproteinase 2 (MMP-2) is activated in hearts upon ischemia-reperfusion (IR) injury and cleaves sarcomeric proteins. It was shown that carvedilol and nebivolol reduced the activity of different MMPs. Hence, we hypothesized that they could reduce MMPs activation in myocytes, and therefore...