Relationship Between Plasma Concentrations and Clinical Effects of Cariprazine in Patients With Schizophrenia or Bipolar Mania

• Main Authors: Antonia Periclou (Author), Susan Willavize (Author), David Jaworowicz (Author), Julie Passarell (Author), Timothy Carrothers (Author), Parviz Ghahramani (Author), Suresh Durgam (Author), Willie Earley (Author), Margit Kapás (Author), Tatiana Khariton (Author)
• Format: Book
• Published: Wiley, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Population pharmacokinetic/pharmacodynamic modeling (via NONMEM) was used to describe longitudinal exposure‐response relationships for total cariprazine (sum of cariprazine and its major active metabolites) in 2,558 patients with schizophrenia or bipolar mania. Drug exposure metrics were explored fo...