Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology

• Main Authors: Marten Szibor (Author), Praveen K. Dhandapani (Author), Eric Dufour (Author), Kira M. Holmström (Author), Yuan Zhuang (Author), Isabelle Salwig (Author), Ilka Wittig (Author), Juliana Heidler (Author), Zemfira Gizatullina (Author), Timur Gainutdinov (Author), German Mouse Clinic Consortium (Author), Helmut Fuchs (Author), Valérie Gailus-Durner (Author), Martin Hrabě de Angelis (Author), Jatin Nandania (Author), Vidya Velagapudi (Author), Astrid Wietelmann (Author), Pierre Rustin (Author), Frank N. Gellerich (Author), Howard T. Jacobs (Author), Thomas Braun (Author)
• Format: Book
• Published: The Company of Biologists, 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Plants and many lower organisms, but not mammals, express alternative oxidases (AOXs) that branch the mitochondrial respiratory chain, transferring electrons directly from ubiquinol to oxygen without proton pumping. Thus, they maintain electron flow under conditions when the classical respiratory ch...