Activation of c-Jun N-Terminal Kinase Cascades Is Involved in Part of the Neuronal Degeneration Induced by Trimethyltin in Cortical Neurons of Mice

• Autores principales: Makoto Shuto (Autor), Keiichi Seko (Autor), Nobuyuki Kuramoto (Autor), Chie Sugiyama (Autor), Koichi Kawada (Autor), Masanori Yoneyama (Autor), Reiko Nagashima (Autor), Kiyokazu Ogita (Autor)
• Formato: Libro
• Publicado: Elsevier, 2009-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

The organotin trimethyltin (TMT) is known to cause neuronal degeneration in the central nervous system. A systemic injection of TMT produced neuronal damage in the cerebral frontal cortex of mice. To elucidate the mechanism(s) underlying the toxicity of TMT toward neurons, we prepared primary cultur...