Activation of c-Jun N-Terminal Kinase Cascades Is Involved in Part of the Neuronal Degeneration Induced by Trimethyltin in Cortical Neurons of Mice

• Main Authors: Makoto Shuto (Author), Keiichi Seko (Author), Nobuyuki Kuramoto (Author), Chie Sugiyama (Author), Koichi Kawada (Author), Masanori Yoneyama (Author), Reiko Nagashima (Author), Kiyokazu Ogita (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The organotin trimethyltin (TMT) is known to cause neuronal degeneration in the central nervous system. A systemic injection of TMT produced neuronal damage in the cerebral frontal cortex of mice. To elucidate the mechanism(s) underlying the toxicity of TMT toward neurons, we prepared primary cultur...