Activation of c-Jun N-Terminal Kinase Cascades Is Involved in Part of the Neuronal Degeneration Induced by Trimethyltin in Cortical Neurons of Mice

The organotin trimethyltin (TMT) is known to cause neuronal degeneration in the central nervous system. A systemic injection of TMT produced neuronal damage in the cerebral frontal cortex of mice. To elucidate the mechanism(s) underlying the toxicity of TMT toward neurons, we prepared primary cultur...

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Autores principales: Makoto Shuto (Autor), Keiichi Seko (Autor), Nobuyuki Kuramoto (Autor), Chie Sugiyama (Autor), Koichi Kawada (Autor), Masanori Yoneyama (Autor), Reiko Nagashima (Autor), Kiyokazu Ogita (Autor)
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Publicado: Elsevier, 2009-01-01T00:00:00Z.
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