Enhanced Intestinal Absorption and Pharmacokinetic Modulation of Berberine and Its Metabolites through the Inhibition of P-Glycoprotein and Intestinal Metabolism in Rats Using a Berberine Mixed Micelle Formulation

• Asıl Yazarlar: Mihwa Kwon (Yazar), Dong Yu Lim (Yazar), Chul Haeng Lee (Yazar), Ji-Hyeon Jeon (Yazar), Min-Koo Choi (Yazar), Im-Sook Song (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2020-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

We aimed to develop a berberine formulation to enhance the intestinal absorption and plasma concentrations of berberine through the inhibition of P-glycoprotein (P-gp)-mediated efflux and the intestinal metabolism of berberine in rats. We used pluronic P85 (P85) and tween 80, which have the potentia...