Enhanced Intestinal Absorption and Pharmacokinetic Modulation of Berberine and Its Metabolites through the Inhibition of P-Glycoprotein and Intestinal Metabolism in Rats Using a Berberine Mixed Micelle Formulation

• Auteurs principaux: Mihwa Kwon (Auteur), Dong Yu Lim (Auteur), Chul Haeng Lee (Auteur), Ji-Hyeon Jeon (Auteur), Min-Koo Choi (Auteur), Im-Sook Song (Auteur)
• Format: Livre
• Publié: MDPI AG, 2020-09-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

We aimed to develop a berberine formulation to enhance the intestinal absorption and plasma concentrations of berberine through the inhibition of P-glycoprotein (P-gp)-mediated efflux and the intestinal metabolism of berberine in rats. We used pluronic P85 (P85) and tween 80, which have the potentia...