Molecular docking and dynamic simulations study for repurposing of multitarget coumarins against SARS-CoV-2 main protease, papain-like protease and RNA-dependent RNA polymerase

• Main Authors: Mai E. Shoman (Author), Amer Ali Abd El-Hafeez (Author), Moteb Khobrani (Author), Abdullah A. Assiri (Author), Sultan S. Al Thagfan (Author), Eman M. Othman (Author), Ahmed R. N. Ibrahim (Author)
• Format: Book
• Published: Pensoft Publishers, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Proteases and RNA-Dependent RNA polymerase, major enzymes which are essential targets involved in the life and replication of SARS-CoV-2. This study aims at in silico examination of the potential ability of coumarins and their derivatives to inhibit the replication of SARS-Cov-2 through multiple tar...