Design, Synthesis and Mechanistic Studies of Novel Isatin-Pyrazole Hydrazone Conjugates as Selective and Potent Bacterial MetAP Inhibitors

• Main Authors: Iram Irfan (Author), Asghar Ali (Author), Bharati Reddi (Author), Mohd. Abrar Khan (Author), Phool Hasan (Author), Sarfraz Ahmed (Author), Amad Uddin (Author), Magdalena Piatek (Author), Kevin Kavanagh (Author), Qazi Mohd. Rizwanul Haque (Author), Shailja Singh (Author), Anthony Addlagatta (Author), Mohammad Abid (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Methionine aminopeptidases (MetAPs) are attractive drug targets due to their essential role in eukaryotes as well as prokaryotic cells. In this study, biochemical assays were performed on newly synthesized Isatin-pyrazole hydrazones (<b>PS1-14</b>) to identify potent and selective bacter...