What is the degree of segregation between striatonigral and striatopallidal projections?

• Main Authors: Jesus eBertran-Gonzalez (Author), Denis eHervé (Author), Jean-Antoine eGirault (Author), Emmanuel eValjent (Author)
• Format: Book
• Published: Frontiers Media S.A., 2010-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In contrast to most other brain regions, in the striatum the output neurons (the medium-sized spiny neurons, MSNs) are GABAergic and act by inhibiting their targets. The standard model of the basal ganglia is built on the segregation of information processing in the direct and indirect pathways, whi...