Evaluation of the Therapeutic Index of a Novel Phosphodiesterase 4B- Selective Inhibitor Over Phosphodiesterase 4D in Mice

• Main Authors: Osamu Suzuki (Author), Kiyoshi Mizukami (Author), Maki Etori (Author), Yoshitaka Sogawa (Author), Nana Takagi (Author), Hiroshi Tsuchida (Author), Kiyoshi Morimoto (Author), Taiji Goto (Author), Toshiharu Yoshino (Author), Tsuyoshi Mikkaichi (Author), Kazuki Hirahara (Author), Satoshi Nakamura (Author), Hiroaki Maeda (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Phosphodiesterase 4 (PDE4) inhibitors have been developed for the treatment of pulmonary inflammatory diseases, but their clinical use was dose-limited by mainly gastric adverse effects. Recent studies suggested PDE4B-selective inhibitors over PDE4D are supposed to display a wider therapeutic index...