Idebenone and coenzyme Q10 are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases

• Главные авторы: Jens Tiefenbach (Автор), Lilia Magomedova (Автор), Jiabao Liu (Автор), Arkadiy A. Reunov (Автор), Ricky Tsai (Автор), Neena S. Eappen (Автор), Rebecca A. Jockusch (Автор), Corey Nislow (Автор), Carolyn L. Cummins (Автор), Henry M. Krause (Автор)
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• Опубликовано: The Company of Biologists, 2018-09-01T00:00:00Z.
• Предметы: article
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Current peroxisome proliferator-activated receptor (PPAR)-targeted drugs, such as the PPARγ-directed diabetes drug rosiglitazone, are associated with undesirable side effects due to robust agonist activity in non-target tissues. To find new PPAR ligands with fewer toxic effects, we generated transge...