Acrylonitrile has Distinct Hormetic Effects on Acetylcholinesterase Activity in Mouse Brain and Blood that are Modulated by Ethanol

• Main Authors: He Yuanqing (Author), Wang Suhua (Author), Xing Guangwei (Author), Ren Chunlan (Author), Qian Hai (Author), Xu Wenrong (Author), Lu Rongzhu (Author), Michael Aschner (Author), Dejan Milatovic (Author)
• Format: Book
• Published: SAGE Publishing, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acrylonitrile(AN) is a neurotoxin both in animals and humans, but its effects on acetylcholinesterase (AChE) activity remain controversial. This study aimed to determine the dose-response effects of AN on AChE activity and the modulatory role of ethanol pretreatment. A total of 144 Kunming mice were...