Epac1 Blocks NLRP3 Inflammasome to Reduce IL-1β in Retinal Endothelial Cells and Mouse Retinal Vasculature

Inflammation is an important component of diabetic retinal damage. We previously reported that a novel β-adrenergic receptor agonist, Compound 49b, reduced Toll-like receptor 4 (TLR4) signaling in retinal endothelial cells (REC) grown in high glucose. Others reported that TLR4 activates high-mobilit...

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Main Authors: Youde Jiang (Author), Li Liu (Author), Elizabeth Curtiss (Author), Jena J. Steinle (Author)
Format: Bog
Udgivet: Hindawi Limited, 2017-01-01T00:00:00Z.
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