Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity

• Main Authors: Paolo Guglielmi (Author), Daniela Secci (Author), Anél Petzer (Author), Donatella Bagetta (Author), Paola Chimenti (Author), Giulia Rotondi (Author), Claudio Ferrante (Author), Lucia Recinella (Author), Sheila Leone (Author), Stefano Alcaro (Author), Gokhan Zengin (Author), Jacobus P. Petzer (Author), Francesco Ortuso (Author), Simone Carradori (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of benzo[b]thiophen-3-ols were synthesised and investigated as potential human monoamine oxidase (hMAO) inhibitors in vitro as well as ex vivo in rat cortex synaptosomes by means of evaluation of 3,4-dihydroxyphenylacetic acid/dopamine (DOPAC/DA) ratio and lactate dehydrogenase (LDH) activi...