Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity

• मुख्य लेखकों: Paolo Guglielmi (लेखक), Daniela Secci (लेखक), Anél Petzer (लेखक), Donatella Bagetta (लेखक), Paola Chimenti (लेखक), Giulia Rotondi (लेखक), Claudio Ferrante (लेखक), Lucia Recinella (लेखक), Sheila Leone (लेखक), Stefano Alcaro (लेखक), Gokhan Zengin (लेखक), Jacobus P. Petzer (लेखक), Francesco Ortuso (लेखक), Simone Carradori (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

A series of benzo[b]thiophen-3-ols were synthesised and investigated as potential human monoamine oxidase (hMAO) inhibitors in vitro as well as ex vivo in rat cortex synaptosomes by means of evaluation of 3,4-dihydroxyphenylacetic acid/dopamine (DOPAC/DA) ratio and lactate dehydrogenase (LDH) activi...