Targeting 14-3-3ζ by a small-molecule compound AI-34 maintains epithelial barrier integrity and alleviates colitis in mice via stabilizing β-catenin

• Main Authors: Yan Li (Author), Nannan Liu (Author), Yao Qian (Author), Chenyang Jiao (Author), Jiashu Yang (Author), Xiangbao Meng (Author), Yang Sun (Author), Qiang Xu (Author), Wen Liu (Author), Jian Cui (Author), Wenjie Guo (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aberrant intestinal epithelial barrier function is the primary pathology of Ulcerative colitis (UC), making it a desirable drug target. In this study, our small-molecule compound AI-34 exerted a significant protective effect in an LPS-induced epithelial barrier injury model. In vitro, AI-34 treatmen...