Selection and Characterization of an α6β4 Integrin blocking DNA Aptamer

• Autori principali: Katharina Berg (Autore), Tobias Lange (Autore), Florian Mittelberger (Autore), Udo Schumacher (Autore), Ulrich Hahn (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2016-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The heterodimeric laminin receptor α6β4 integrin plays a central role in the promotion of tumor cell growth, invasion, and organotropic metastasis. As an overproduction of the integrin is often linked to a poor prognosis, the inhibition of integrin α6β4 binding to laminin is of high therapeutical in...