A dog model for centronuclear myopathy carrying the most common DNM2 mutation

• Main Authors: Johann Böhm (Author), Inès Barthélémy (Author), Charlène Landwerlin (Author), Nicolas Blanchard-Gutton (Author), Frédéric Relaix (Author), Stéphane Blot (Author), Jocelyn Laporte (Author), Laurent Tiret (Author)
• Format: Book
• Published: The Company of Biologists, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mutations in DNM2 cause autosomal dominant centronuclear myopathy (ADCNM), a rare disease characterized by skeletal muscle weakness and structural anomalies of the myofibres, including nuclear centralization and mitochondrial mispositioning. Following the clinical report of a Border Collie male with...