Plasmodium vivax Reticulocyte Binding Proteins Are Key Targets of Naturally Acquired Immunity in Young Papua New Guinean Children.

• Main Authors: Camila T França (Author), Wen-Qiang He (Author), Jakub Gruszczyk (Author), Nicholas T Y Lim (Author), Enmoore Lin (Author), Benson Kiniboro (Author), Peter M Siba (Author), Wai-Hong Tham (Author), Ivo Mueller (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Major gaps in our understanding of Plasmodium vivax biology and the acquisition of immunity to this parasite hinder vaccine development. P. vivax merozoites exclusively invade reticulocytes, making parasite proteins that mediate reticulocyte binding and/or invasion potential key vaccine or drug targ...